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Human growth hormone is used to treat a large number of disorders in children and adults (mainly in those with an insufficient amount of natural hormone). HGH is the main hormone that stimulates linear growth. It promotes the growth of bones, internal organs, muscle tissue. The main effects of HGH on bone tissue include stimulation of cartilage growth and protein synthesis.
GH has also been approved for the treatment of delayed growth in Turner syndrome and progressive renal failure in children. HGH for sale is also in demand in AIDS patients. It is used as a substitution therapy for GH deficiency in adults. Specific application for growth hormone: chondrodysplasia in children, delayed growth associated with intrauterine growth retardation, Prader-Willie syndrome, Noonan syndrome, certain debilitating diseases (ulcers, burns, cancer).
There are congenital and acquired HGH deficiencies; organic (as a result of intracranial damage of various etiologies) and idiopathic (in the absence of any specific organic pathology of the hypothalamic-pituitary region). Congenital growth hormone deficiency occurs as a result of a primary impairment of HGH secretion by the hypothalamus, which is unable to adequately stimulate the somatotrophs. Acquired somatotropic insufficiency occurs as a result of hypothalamic-pituitary region surgery or inflammatory diseases.
Recombinant HGH preparations have been used in clinical practice since 1985. Therapeutic benefits of HGH injections in patients with HGH deficiency are undisputed. These preparations help improve your strength and gain more muscle mass. Moreover, these drugs also have a beneficial effect on bone mass and bone tissue metabolism.
Substitution therapy with recombinant human growth hormone preparations is highly effective. It is possible to achieve genetically programmed growth rates in case of regular treatment.
In addition to linear growth, certain changes in the hormonal, metabolic, and psychic status of patients are noted during HGH therapy. These benefits include increased muscle strength, increased cardiac output, increased absorption of calcium in the intestine, improvement of renal blood flow, etc. Thus, the quality of life improves significantly.
According to present knowledge, the main factors of mortality are heart diseases. Cardiovascular diseases kill 1.5 million people every year. Patients with somatotropin deficiency have a decreased sensitivity to insulin. Thus, it can be said that these patients die more often from cardiovascular diseases. Thanks to various studies, there is growing evidence that HGH therapy can prevent these dangerous diseases.
So, let’s list all the positive reactions associated with the normalization of HGH level:
- HGH improves myocardial function;
- HGH reduces the risk of myocardial infarction in the elderly;
- HGH has a positive effect on lipid metabolism;
- HGH helps protect your body from osteoporosis;
- HGH helps increase muscle tissue growth and strength (even without regular physical exertion).
What are the functions of growth hormone?
Growth hormone (HGH, GH, somatotropin) is a substance produced and secreted by the anterior pituitary gland. HGH production is higher in puberty and lower during middle age (with an average rate of 15% after 20 years).
GH stimulates both linear growth and growth of internal organs. It also has a significant impact on the metabolism of proteins, fats and carbohydrates. When used regularly, HGH regulates glucose metabolism, increases lipolysis and muscle mass and lowers the level of cholesterol. Many of the effects are associated with insulin-like growth factor-1 (IGF-1), which is also known as somatomedin C. HGH stimulates the production of IGF-1 in peripheral tissues (mainly in the liver).
Somatotropin is produced cyclically. It has several peaks per day: during night sleep, during meals and physical activity. The greatest productivity has been observed in individuals up to 20-25 years of age. The production of somatotropin gradually slows by the age of 30. In this connection, a slight decrease in immunity is observed. By the age of 40-45, the growth hormone secretion is 50% or less than in previous years. At the same time, signs of physiological aging become more pronounced.
Somatotropin has a modulating effect on certain functions of the central nervous system. It is involved in the regulation of CNS activity. Excessive GH secretion in childhood causes gigantism. The result of excess GH production in adults is acromegaly. Insufficient production of GR in childhood causes low growth (dwarfism), loss of hair and mental retardation. As for GH deficiency in adults, this pathology is mainly caused by surgical interventions or radiation therapy. Such patients suffer from weakness, fatigue, low muscle mass and obesity.
The main goals of somatotropin therapy are different in children and adults. HGH in adults has the following indications: it helps restore normal balance of fat and muscle tissue, improve muscle strength and myocardial function, and improve the quality of life. Growth hormone is used not only in adults with HGH insufficiency, but also in adult patients with diseases accompanied by increased catabolism (for example, burns), as well as in elderly patients with decreased growth hormone secretion. As for children, the main goal of treatment is to normalize linear growth.
HGH course is recommended for bodybuilders who want to add more lean mass and reduce subcutaneous fat at the same time. In comparison with anabolic steroids, HGH for sale is a good choice with minimal side effects. Moreover, it does not affect the potency. Athletes taking growth hormone in the form of injections note that this hormone has a positive effect on fat burning and bone strengthening processes. That is why HGH courses are so popular among weightlifters. Of course, it is necessary to consult a doctor before starting long-term therapy.
HGH was produced in its pure form only in the early 1970s. Nowadays, absolutely safe synthetic analogs of somatotropin are used.
What are the therapeutic doses of HGH?
The recommended dose for children is 0.3 mg/kg per week in case of GH deficiency, 0.35 mg/kg per week in case of growth problems associated with chronic renal failure and 0.375 mg/kg per week in case of Turner syndrome. The dose can be divided into two or three injections a week. Daily injections lead to a better effect. The dose for adult patients is 0.025 mg/kg per day. HGH for sale is available in the form of subcutaneous injections.
What are the side effects of HGH?
Edema and carpal tunnel syndrome are the most common problems in adults, but not in children. False brain tumor symptoms have been described in children with GH deficiency and Turner syndrome. HGH therapy is associated with a high risk of femoral head dislocation. Gynecomastia, arthralgia and myalgia may develop in elderly patients. Violation of carbohydrate metabolism and diabetes are not so common (mostly in patients with risk factors).
HGH for sale can cause hyperinsulinemia in some patients. Somatotropin acts as an antagonist of another peptide hormone – insulin. Somatotropic hormone regulates carbohydrate metabolism and increases the level of glucose. In turn, this can cause dysfunction of the thyroid gland and insulin-dependent diabetes.
Somatotropin therapy is not associated with high risks of leukemia or other tumors, although there is a general rule that children should not take recombinant HGH preparations during the first year after treatment of leukemia. In addition, somatotropin therapy is associated with the following symptoms: increased pigmentation, gynecomastia, pancreatitis and benign intracranial hypertension, but these phenomena are rare.
In general, growth hormone treatment is safe. It is not accompanied by dangerous side effects. There are many myths about the fact that this is a very harmful drug. However, there will be no side effects if everything is done correctly. It is important to follow your doctor’s recommendations to get the most out of GHG therapy.